The evidence ‘spokes’ encircling the wheel serves as support for appropriate clinical behaviors and decisions. These spokes can represent different forms of evidence, allowing a research medium that best addresses the patient’s condition and includes all relevant science disciplines. Biopsychosocial constructs and practices comprise the wheel’s ‘rim,’ providing a foundation for consistent care. The clinician’s systematic management approach serves as the management ‘tire,’ providing a conduit of care to the patient. This approach can create an opportunity to develop a ‘Knowledge Transfer,’ which will be facilitated by research that clearly states the findings’ potential clinical relevance.